Illustrative estimate only - not verified by this sponsor. Contact the study team for actual compensation.
The purpose of this study is to find out why patients with chronic kidney disease (CKD) have poor exercise capacity and what causes an increase in blood pressure during exercise (i.e. increased adrenaline levels, or decreased ability of blood vessels to dilate).
What happens when you apply
Reach out via phone or email to express interest
Brief call to discuss your health history
Medical screening at the research site
Begin your journey in the study
Inclusion Criteria: * Veterans with Stages III and IV Chronic Kidney Disease (CKD) * Kidney transplant recipients with varying degrees of kidney function * Veterans 18-75 years old, without kidney disease, as study controls * Exercise less than 20 minutes twice per week * Willing and able to cooperate with the protocol Exclusion Criteria: * Severe CKD (estimated glomerular filtration rate (eGFR) \< 15 cc/minute) * Metabolic alkalosis (serum bicarbonate \> 28 meq/L) * Ongoing drug or alcohol abuse * Diabetic neuropathy * Any serious systemic disease that might influence survival * Severe anemia with hemoglobin (Hbg) level \< 10 g/dL * Clinical evidence of congestive heart failure or ejection fraction below 35% * Symptomatic heart disease determined by prior electrocardiogram, stress test, and/or history * Treatment with central alpha agonists (clonidine) * Uncontrolled hypertension with blood pressure (BP) greater than 170/100 mmHg * Low blood pressure with BP less than 100/50 mmHg * Pregnancy or plans to become pregnant * Current treatment with monoamine oxidase inhibitors (MAOIs) * Inability to exercise on a stationary bicycle
imaguineapig pulls live data from ClinicalTrials.gov (NIH/NLM).Illustrative estimate only - not verifiedPay estimates are approximate ranges based on study type and are not confirmed by sponsors — actual compensation may differ. Eligibility indicators use limited criteria (age, sex) only. We do not provide medical advice. Always contact the study team directly to confirm compensation, full eligibility, and risks before enrolling.