Illustrative estimate only - not verified by this sponsor. Contact the study team for actual compensation.
The purpose of this research is to determine whether there is more extensive inflammation in the brain of people with clinical evidence of neuropsychiatric syndromes, such as mood disorder, chronic pain syndrome, dementia, traumatic brain injury, or substance abuse. The research will also explore whether there is more inflammation in patients with more neuropsychiatric symptoms. Inflammation in the brain will identified by using Positron Emission Tomography (PET) with the radiotracer \[11C\]PBR-28 or \[11C\]ER176.
What happens when you apply
Reach out via phone or email to express interest
Brief call to discuss your health history
Medical screening at the research site
Begin your journey in the study
Inclusion Criteria: * Must be between 18-80 years old * Males or females * Must be right handed * Must be able to sit unaccompanied for long periods of time with little body movement * Must be illicit drug free at time of scanning as appropriate (UDS negative), * Must be either healthy (without medical, neurological, psychiatric illness) or have a diagnosis of a neuropsychiatric syndrome (mood disorder, chronic pain syndrome, dementias, traumatic brain injury, substance/alcohol use disorder). * Healthy Control volunteers must be medication free (≥ 14 days) * Illicit drug free at time of scanning (verified by negative urine drug screen) Exclusion Criteria: * Must not be a smoker. * Females must not be pregnant or nursing. * Must not suffer from claustrophobia * Must not meet exclusion criteria for MRI scanning (i.e. non-fixed magnetisable objects) * Must not be PBR-28 low affinity binder (or using the \[11C\]ER176 study radiotracer) * Healthy control volunteers must not have on-going, chronic, or relapsing/remitting medical, psychiatric (absence of both DSM-IV Axis I and/or Axis II disorders), or neurological illness as determined by combination of history, medical record, and/or examination.
imaguineapig pulls live data from ClinicalTrials.gov (NIH/NLM).Illustrative estimate only - not verifiedPay estimates are approximate ranges based on study type and are not confirmed by sponsors — actual compensation may differ. Eligibility indicators use limited criteria (age, sex) only. We do not provide medical advice. Always contact the study team directly to confirm compensation, full eligibility, and risks before enrolling.