Illustrative estimate only - not verified by this sponsor. Contact the study team for actual compensation.
The first objective of the study is to evaluate whether a novel bio-signature (derived from a wide range of pro- and anti-nociceptive IL-1 family cytokine activity) will predict pain experienced and also release of underlying endogenous opioid neurotransmitters during an experimental nociceptive pain challenge, which will be performed while simultaneously quantifying mu-opioid receptor activity in the brain via \[11C\]-carfentanil PET neuroimaging in healthy subjects. Another objective is to evaluate whether an anti-inflammatory drug that reduces activation of IL-1b (minocycline) will perturb the balance between pro- and anti-nociceptive IL-1 cytokines and effect a reduction in pain experienced (and endogenous opioids released) during the experimental, nociceptive pain challenge. A final objective is to evaluate performance characteristics (sensitivity, accuracy, dynamic range) of the biosignature for the purpose of predicting post-operative pain.
What happens when you apply
Reach out via phone or email to express interest
Brief call to discuss your health history
Medical screening at the research site
Begin your journey in the study
Inclusion Criteria: * Obese or non-obese * Awaiting elective surgery * Negative urine pregnancy test Exclusion Criteria: * Active, severe medical or psychiatric illness (per DSM-V) * History of depressive and/or anxiety symptoms with or without presence of a DSM-V depressive and/or anxiety disorder * Current or recent (within past 3 months) suicidal thoughts/plans/attempts * Current or recent (within past 3 months) substance use/abuse/dependence (Note: stable nicotine use is acceptable, non-risky alcohol use is acceptable) * Active or chronic medical illness (except obesity: either obese or non-obese volunteers can enroll in the study). * MRI exclusion criteria including presence of non-MRI-safe medical device(s), magnetizable objects in soft tissue, severe claustrophobia, etc. * Recent (past year) PET scan(s). * Lifetime excessive radiation exposure that would be exclusionary via standards of the local radiation safety committee. * Current medication treatment that would impact measures of interest. * Current pregnancy or recent (within the past 2 months) intercourse without an acceptable contraceptive method * Exclusion criteria for Anakinra treatment.
imaguineapig pulls live data from ClinicalTrials.gov (NIH/NLM).Illustrative estimate only - not verifiedPay estimates are approximate ranges based on study type and are not confirmed by sponsors — actual compensation may differ. Eligibility indicators use limited criteria (age, sex) only. We do not provide medical advice. Always contact the study team directly to confirm compensation, full eligibility, and risks before enrolling.