Targeting Specific Brain Networks to Treat Specific Symptoms in Depression

Inclusion Criteria for healthy participants:

* 18-65 years of age
* Capacity to provide informed consent form to participate in the study

Inclusion Criteria for participants with Major Depressive Disorder (MDD):

* 18-65 years of age
* Capacity to provide informed consent form to participate in the study
* Currently in a major depressive episode. Comorbid anxiety disorders and personality disorders will be allowed provided that MDD is the primary diagnosis.

Exclusion Criteria for all participants:

* Meeting criteria, in the past or currently, for bipolar affective disorder, hypomania or mania.
* Meeting criteria, in the past or currently, for a primary psychotic disorder (e.g., schizophrenia).
* Neurological conditions with known structural brain lesions, e.g., intracranial masses, multiple sclerosis.
* Any personal history of seizures or a family history of epilepsy in a first-degree relative.
* Metal in the body that is ferromagnetic or metallic injury to the eyes.
* Implanted pacemakers, medication pumps, vagal stimulators, deep brain stimulators, or ventriculoperitoneal shunts, etc.
* Substance abuse or dependence that is current and active within the last six months, as indicated by self-report (e.g., heroin, cocaine, methamphetamines).
* Inability to meet the safety criteria for MRI scanning for any other reason.
* Severe or unstable medical illness.
* Currently pregnant, as assessed with urine pregnancy test in women of childbearing age.