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Topical 10% Povidone-Iodine in Preventing White Spots

Sponsor

University of Washington

Pharma

Typical Pay Range

$500 – $7,000

Illustrative estimate only - not verified by this sponsor. Contact the study team for actual compensation.

About This Study

The goal of this clinical trial is to learn if topical application on the all surface of 10% Povidone Iodine (Povi-One) in healthy participants in transitional or permanent dentition (10-17 y) prevents new white spot lesions in the maxillary anterior teeth at 1 year of follow-up. Researchers will compare Povi-One to a placebo to see if Povi-One works to prevent new white spot lesions. It will also learn about the safety of topical 10% Povidone Iodine. The main questions it aims to answer are: 1. Does Povi-One prevent the development of any white spot lesion on the surface of maxillary anterior teeth? 2. Does Povi-One lower the probability of any International Caries Detection and Assessment System (ICDAS) score greater than 0 and mean modified Löe-Silness Gingival Index (GI) in the intervention group? Researchers will 1. Score GI without cleaning participants teeth, then score ICDAS of maxillary and mandibular incisors after participants brush and floss their teeth and take a photograph of maxillary 6 anterior teeth 2. Apply Povi-one (or control) at the consultation appointment before placing fixed orthodontic appliances and 3, 6, and 9 months after appliance placement Researchers will 1. Recall using Zoom 24-48 hours after the first application of Povi-One and examine the participant's mouth for oral lesions using a structured paper checklist 2. Interview the caregiver to complete a paper questionnaire on adverse effects Researchers will 1. Score GI, and then score ICDAS of maxillary and mandibular incisors in 6, 12 months after appliance placement 2. Evaluate the development of white spot lesions on maxillary central and lateral incisors in 6, and 12 months after appliance placement

Your Journey

What happens when you apply

📞

Contact Study Team

5 min

Reach out via phone or email to express interest

💬

Phone Screening

15-30 min

Brief call to discuss your health history

🏥

In-Person Visit

2-4 hours

Medical screening at the research site

🚀

Start Participation

Varies

Begin your journey in the study

Questions to Ask

What's the exact compensation schedule?

What are the potential side effects?

Can I withdraw at any time?

Phase

Phase 2

Enrollment

80 participants

Sites

1 location

Timeline

Sep 2024 - Mar 2027

What's Involved

PlaceboPovidone-iodine solution

Conditions Studied

White Spot LesionsGingival Inflammation and Bleeding

Study Locations

University of Washington, School of Dentistry Department of Orthodontics, 1959 NE Pacific St. Health Sciences Center

Seattle, Washington, United States

Eligibility

Min Age:10 Years

Max Age:17 Years

Sex:ALL

Full Criteria

Inclusion Criteria:

* Healthy children and teens (10-17 years old)
* Transitional or permanent dentition of at least 4 permanent anterior teeth in each arch
* Full fixed appliance orthodontic treatment is expected to last at least one year

Exclusion Criteria:

* Allergies to iodine
* Chronic prophylactic use of antibiotics
* Diagnosis of thyroid disease
* Conditions that could impair routine oral hygiene procedures.
* Pregnant at enrollment

NCT06616207

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Seattle, Washington

imaguineapig pulls live data from ClinicalTrials.gov (NIH/NLM).Illustrative estimate only - not verifiedPay estimates are approximate ranges based on study type and are not confirmed by sponsors — actual compensation may differ. Eligibility indicators use limited criteria (age, sex) only. We do not provide medical advice. Always contact the study team directly to confirm compensation, full eligibility, and risks before enrolling.