LUNG-07: Advancing Precision-Based Lung Cancer Screening: Implementation, AI-Guided Risk Stratification, and Biomarker Integration (CREST AI)

Inclusion Criteria:

* Age 50-80 years at the time of consent
* Meets at least one of the following LCS eligibility criteria:

  * USPSTF: ≥20 pack-years, currently smoke or quit ≤15 years ago.
  * Potter: 20 years of smoking, regardless of intensity
  * ACS: ≥20 pack-years, no restriction on quit time
* Receiving or scheduled for LDCT through the UI Health Lung Screening Program.
* Willing to view a short (approximately 2-minute) educational video that explains Sybil AI scoring and LCS, complete the Sybil AI survey (if selected), and/or provide blood samples (optional).
* Able to provide written informed consent and HIPAA authorization for release of personal health information, via an approved UIC IRB ICF and HIPAA authorization.
* Women of childbearing potential must not be pregnant or breastfeeding. A negative serum or urine pregnancy test is required per institutional practice guidelines.
* As determined at the discretion of the enrolling physician or protocol designee, the ability of the subject to understand and comply with study procedures for the entire length of the study

Exclusion Criteria:

* Inability to undergo LDCT
* Current diagnosis or history of lung cancer \< 5 years prior to study enrollment.
* Life expectancy \<1 year
* Active lung infection requiring systemic therapy
* Vulnerable population, including prisoners and pregnant or nursing women, will not be enrolled due to radiation exposure from LDCT, which is contraindicated in pregnancy.
* Other major comorbidity, as determined by the study PI
* Any mental or medical condition that prevents the patient from giving informed consent or participating in the trial.