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Spatial Scene Recognition Memory in Epilepsy Surgery

Sponsor

University of California, Davis

Brain & Neuro

Typical Pay Range

$50 – $1,000

Illustrative estimate only - not verified by this sponsor. Contact the study team for actual compensation.

About This Study

This study investigates the anatomical and physiological basis of spatial scene recognition memory in patients with temporal lobe epilepsy and temporal lobe lesions. Standard neuropsychological tests are insensitive to important memory deficits experienced by patients, particularly in spatial/scene memory, recollective experience, and familiarity processing. Using a validated virtual tour paradigm, the study examines how familiarity-based recognition and recall of spatial scenes relate to specific brain structures. In Aim I, a large cohort of patients with varied temporal lobe lesions at Emory University undergoes the virtual tour task with voxel-based lesion-symptom mapping to localize necessary brain regions. In Aim II, scalp event-related potentials and eye tracking in healthy participants at UC Davis characterize the temporal dynamics and lateralization of scene recognition. In Aim III, intracranial EEG recordings (including local field potentials and single-unit activity) in epilepsy surgery patients at UC Davis determine the precise network dynamics underlying spatial scene familiarity and recall. The long-term goal is to improve the prediction and prevention of cognitive morbidity from epilepsy surgery by providing a more complete model of spatial recognition memory circuits.

Your Journey

What happens when you apply

📞

Contact Study Team

5 min

Reach out via phone or email to express interest

💬

Phone Screening

15-30 min

Brief call to discuss your health history

🏥

In-Person Visit

2-4 hours

Medical screening at the research site

🚀

Start Participation

Varies

Begin your journey in the study

Questions to Ask

What's the exact compensation schedule?

What are the potential side effects?

Can I withdraw at any time?

Phase

N/A

Enrollment

620 participants

Sites

2 locations

Timeline

Jul 2024 - Jun 2030

What's Involved

Virtual Tour Recognition Memory TaskIntracranial EEG Recording with Research Electrodes (Aim III only)MRI Neuroimaging and Neuropsychological Assessment (Aim I)

Conditions Studied

Focal EpilepsyTemporal Lobe EpilepsyMedically Refractory EpilepsyMemory DisordersEpilepsy ComorbiditiesEpilepsy IntractableEpilepsy SurgeryEpilepsy, Temporal LobeMemory DeficitsMemory Disorder, SpatialMemory DysfunctionSpatial Perception

Study Locations

UC Davis Medical Center

Sacramento, California, United States

Emory University Hospital

Atlanta, Georgia, United States

Eligibility

Min Age:18 Years

Max Age:55 Years

Sex:ALL

Full Criteria

Inclusion Criteria:

* Age 18 years or older
* For Aims I and III: Diagnosis of focal epilepsy or temporal lobe lesion; patients undergoing evaluation for or having undergone epilepsy surgery
* For Aim II: Healthy adult participants
* Full-Scale IQ ≥ 70
* English proficiency sufficient to understand and complete the task
* For Aim I: Enrolled in or eligible for Emory University epilepsy surgery research registry
* For Aim III: Undergoing clinically indicated stereoelectroencephalography (SEEG) at UC Davis Medical Center
* Able to provide informed consent (or for Aim I retrospective component, prior consent in Emory registry)

Exclusion Criteria:

* Full-Scale IQ \< 70
* Inability to provide informed consent
* For Aim III: Age \> 55 years
* For Aim II: History of neurological or psychiatric disorder (as applicable per study protocol)

NCT07580183

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imaguineapig pulls live data from ClinicalTrials.gov (NIH/NLM).Illustrative estimate only - not verifiedPay estimates are approximate ranges based on study type and are not confirmed by sponsors — actual compensation may differ. Eligibility indicators use limited criteria (age, sex) only. We do not provide medical advice. Always contact the study team directly to confirm compensation, full eligibility, and risks before enrolling.